Molecular Docking and ADME Analysis of L-Phe -L-Tyr Dipeptide

Hypertension is a serious risk factor for various diseases. Therefore, lowering and preventing high blood pressure significant issue. Blockage of the renin-angiotensin-aldosterone system (RAAS), which controls pressure, important to reduce consequently symptoms heart failure. This blockage can be carried out by angiotensin-converting enzyme (ACE) angiotensin II receptor blockers (ARBs). The phenylalanyltyrosine (H-Phe-Tyr-OH, Phe-Tyr, L-Phe-L-Tyr, L-phenylalanyl-L-tyrosine) dipeptide examined in this study an structure that shows properties. For reason, potential peptide ACE inhibitor or ARB was investigated. molecular activity Phe-Tyr compared with antihypertensive drugs using theoretical calculations. Molecular docking method, one these methods, has considerable process illuminating biochemical processes investigating interactions (ligands) targeted receptors. In study, analyses H-Phe-Tyr-OH Angiotensin type 1 (AT1R) were implemented. interaction types regions also determined comparison drug molecules (Captopril, Enalapril, Telmisartan Eprosartan) are inhibitors ARBs. Lastly, ADME (absorption, distribution, metabolism, excretion) analysis performed estimate its potential. pharmacokinetic properties mechanism action AT1R investigated first time